Dan, Use the TMG logs to discover what process name is making the calls and use the TMG Client configuration in the TMG console to disable TMG client for that app. From: isalist-bounce@xxxxxxxxxxxxx [mailto:isalist-bounce@xxxxxxxxxxxxx] On Behalf Of Ball, Dan Sent: Thursday, March 22, 2012 8:10 AM To: 'isalist@xxxxxxxxxxxxx' Subject: [isalist] TMG Client vs Cisco VPN Client What is the best way to get the TMG client to play nicely with the Cisco AnyConnect VPN client? The TMG client is intercepting the calls to the VPN client and routing them through the Internet. When I disable the TMG client, it works properly.