SMTP NOT WORKING VIA ISA

Dear All,
Could you pls assist me to solve the problem am facing
on Isa. 
After configuring  isa to protect exchange 2000 , i
can not send mails any more but i can download mails.
telnet of port 25 and 110 works well on isa.
but not successful on exchange 2000.

pls assist.



                
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