[ExchangeList] CAS question

Hello,
 
In exchange 2003 inorder to configure front end server we need to have the same virtual servers/virtual directories created both on front end server and back end server.
 
If i have client access machines running solely on 1 or 2  machines and mailbox servers running on other machines, how would be the config ?  Do we have to drill down iis and create it exactly like we did in exchange 2003.
 
Any help greatly appreciated.
 
Thanks
Raj

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