[esnr] AW: Re: Dyslexia and ERPs

  • From: "Ralph Warnke" <ralph.warnke@xxxxxxxxxxx>
  • To: <esnr@xxxxxxxxxxxxx>
  • Date: Tue, 5 Oct 2004 14:57:06 +0200

Dear Wolfgang,
please send this article backchannel to me, too. Thank you.
Best regards,
Mit herzlichen Grüßen
aus der Wedemark
(Ralph Warnke)
MediTECH Electronic GmbH
Langer Acker 7
D-30900 Wedemark
Telefon: 05130 - 97778-0
Telefax: 05130 - 97778-22
www.meditech.de <http://www.meditech.de/> 
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www.brainfeedback.de <http://www.brainfeedback.de/> 
-----Ursprüngliche Nachricht-----
Von: esnr-bounce@xxxxxxxxxxxxx [mailto:esnr-bounce@xxxxxxxxxxxxx] Im
Auftrag von Wolfgang Keeser
Gesendet: Dienstag, 5. Oktober 2004 14:55
An: esnr@xxxxxxxxxxxxx
Betreff: [esnr] Re: Dyslexia and ERPs

There was also a good review article in the september issue of Nature
Review Neuroscience by Paula Tallal Improving language and literacy is a
matter of time
Abstract | Developmental deficits that affect
speech perception increase the risk of
language and literacy problems, which can
lead to lowered academic and occupational
accomplishment. Normal development and
disorders of speech perception have both
been linked to temporospectral auditory
processing speed. Understanding the role
of dynamic auditory processing in speech
perception and language comprehension
has led to the development of
neuroplasticity-based intervention strategies
aimed at ameliorating language and literacy
problems and their sequelae.

PDF copies available back channel too.

Wolfgang Keeser
Am 05.10.2004 um 13:49 schrieb Gruzelier, John H:

Have copied this off the journal website. Copies available back channel.

Original Article 

Impaired auditory frequency discrimination in dyslexia detected with
mismatch evoked potentials
Torsten Baldeweg, MD *, Alexandra Richardson, PhD, Sarah Watkins, MBBS,
Christine Foale, MBBS, John Gruzelier, MA, PhD 
Division of Neuroscience and Psychological Medicine, Imperial College
School of Medicine, London, UK   
*Correspondence to Torsten Baldeweg, Institute of Child Health and Great
Ormond Street Hospital for Children NHS Trust, University College London
Medical School, The Wolfson Centre, Mecklenburgh Square, London WC1N


Deficits in phonological skills appear to be at the heart of reading
disability; however, the nature of this impairment is not yet known. The
hypothesis that dyslexic subjects are impaired in auditory frequency
discrimination was tested by using an attention-independent auditory
brain potential, termed mismatch negativity (MMN) while subjects
performed a visual distractor task. In separate blocks, MMN responses to
graded changes in tone frequency or tone duration were recorded in 10
dyslexic and matched control subjects. MMN potentials to changes in tone
frequency but not to changes in tone duration were abnormal in dyslexic
subjects. This physiological deficit was corroborated by a similarly
specific impairment in discriminating tone frequency, but not tone
duration, which was assessed separately. Furthermore, the pitch
discrimination and MMN deficit was correlated with the degree of
impairment in phonological skills, as reflected in reading errors of
regular words and nonwords. It is possible that in dyslexia a persistent
sensory deficit in monitoring the frequency of incoming sound may impair
the feedback control necessary for the normal development of
phonological skills. Ann Neurol 1999;45:495-503  

Received: 25 June 1998; Revised: 15 December 1998; Accepted: 16 December

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