[accessibleimage] Re: "molecular music" Genes come alive with the sound of music

Thanks,

They all work now but huntington comes up and refuses to play.

Interesting!

----- Original Message ----- 
From: "Vince Thacker" <vince@xxxxxxxxxxxxxxxxxxxxx>
To: <accessibleimage@xxxxxxxxxxxxx>
Sent: Tuesday, May 08, 2007 12:15 PM
Subject: [accessibleimage] Re: "molecular music" Genes come alive with the 
sound of music


David, you may find that it's OK again now. I've just been playing audio
from the 'Examples' page. Some other pages are giving out server errors,
though.

Vince.
----- Original Message ----- 
From: "David Poehlman" <poehlman1@xxxxxxxxxxx>
To: <accessibleimage@xxxxxxxxxxxxx>
Sent: Tuesday, May 08, 2007 4:08 PM
Subject: [accessibleimage] Re: "molecular music" Genes come alive with the
sound of music


>I get a server error when trying to play a sample.
>
> ----- Original Message ----- 
> From: "Lisa Yayla" <fnugg@xxxxxxxxx>
> To: <accessibleimage@xxxxxxxxxxxxx>;
> <art_beyond_sight_learning_tools@xxxxxxxxxx>;
> <art_beyond_sight_advocacy@xxxxxxxxxx>; "Art Beyond Sight Educators List
> a"
> <art_beyond_sight_educators@xxxxxxxxxx>;
> <art_beyond_sight_theory_and_research@xxxxxxxxxxx>; "Access to Art
> Museums"
> <artbeyondsightmuseums@xxxxxxxxxx>
> Sent: Tuesday, May 08, 2007 4:25 AM
> Subject: [accessibleimage] "molecular music" Genes come alive with the
> sound
> of music
>
>
> Hi,
> Interesting article from Nature about research done to convert DNA
> information to music.
> Enclosing excerpt of article and link to research site Gene2Music
> "The primary goal of this work is to convert genome-encoded protein
> sequences into musical notes in order to hear auditory protein patterns."
> Very interesting information there about Art and science and for a bit
> of light "molecular music" also can listen to examples at the site.
> Regards,Lisa
>
> examples
> Gene2Music
> http://www.mimg.ucla.edu/faculty/miller_jh/gene2music/home.html
> http://www.mimg.ucla.edu/faculty/miller_jh/gene2music/examples.html
> Art and Science
> http://www.mimg.ucla.edu/faculty/miller_jh/gene2music/artscience.html
> Nature
> http://www.nature.com/news/2007/070430/full/070430-7.html
> excerpt
> Genes come alive with the sound of music
> Molecular geneticists riff with strings of protein-coding DNA.
>
> Check out the Gene2Music site to play your favourite protein.
>
> Punchstock
>
> Imagine humming along to horse haemoglobin or tapping your toes to
> transcription factors. Now you can, thanks to a pair of molecular
> biologists who have developed a way to turn such proteins into music.
>
> Rie Takahashi, a graduate student in molecular genetics who has studied
> the piano since she was a child, developed the method as part of an
> undergraduate project for her supervisor, Jeffrey Miller. She says they
> were inspired, in part, by a blind meteorology graduate student at
> Cornell University in Ithaca, New York, who developed a way of reading
> weather maps by converting the different colour gradations of a map into
> a range of tones.
>
> They wondered whether something similar could help both the sighted and
> the visually impaired to visualize proteins, which are made up of amino
> acids coded for by 'letters' of DNA in a gene. "We wanted to be able to
> move away from a two-dimensional string of letters across a sheet of
> paper, and to see if adding another dimension — sound — would help,"
> says Takahashi.
>
> So Takahashi and Miller, who are based at the University of California,
> Los Angeles, developed a way of converting each of the 20 standard amino
> acids from which proteins are built into different piano chords. When
> played, the amino acids form a slightly disharmonious, but not
> altogether unpleasant tune, they report in Genome Biology1.
>
> The project, called Gene2Music, isn't the first to convert biological
> structures into music2,3, but Takahashi says it differs from its
> predecessors because the chord assignment limits the music to within a
> one-and-a-half octave spread, making it, in her opinion, more pleasing
> to the ear.
>
> More water-loving or hydrophilic amino acids have been assigned a chord
> in a higher key, while water-hating or hydrophobic ones are lower. So
> similar amino acids sound alike. And the duration for which a chord is
> played is determined by the prevelance of its 'codon' (the three DNA
> letters that make up an amino acid) in the sequence. So amino acids that
> make up a good chunk of a protein will be played for longer than those
> that are rare within the protein. This gives the piece a rhythm that
> says something about the repetitive structure of the protein.
>
>
>
>
>
>


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